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KMID : 0360320010330040302
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Journal of Korean Cancer Research Association
2001 Volume.33 No. 4 p.302 ~ p.308
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Expressions of Multidrug Resistance - Related Genes in Gastric Cancer Tissue and Normal gastric Mucosal Tissue
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Song Seok-Hun
Kim Sang-Woon
Song Sun-Kyo
Choi Joon-Hyuk
Ha Jeoung-Hee
Lee Kyoung-Hee
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Abstract
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Purpose: This study was conducted to evaluate the expressions of the mdr1 gene and the MRP gene in tumor and adjacent normal gastric tissues.
Materials and Methods: The specimens were obtained from 53 patients who had gastric cancer. None of these patients had received any kind of preoperative chemo-therapy. The reverse transcription polymerase chain reaction and immunohistochemical stain were used to check the level of expressions of mRNAs and their associated proteins .
Results: Highly positive expressions of mdr1 mRNA, MRP mRNA, p-glycoprotein, and MRP (multidrug resistance associated protein) were observed in the tumor and the adjacent normal tissues. Most tumor tissues coex-pressed mdr1 mRNA and MRP mRNA significantly (p ＜0.001). The expression of these genes in the tumor was muchstronger than in the normal counterpart tissues. The expression of the p-glycoprote in was correlated only with the pathological stage (p＜0.05). MRP expression was correlated with lymph node metastas is (p＜0.05).
Conclusion: Normal gastric tissue showed strong physiologic expressions of the mdr1 and MRP genes. Overexpressions of these genes were observed in gastric cancer tissue. The presence of multidrug resistances hould be considered when planning anticancer che-motherapy for treating gastric cancer.
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KEYWORD
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Stomach neoplasm, Multidrug resistance, p-glycoprotein, Multidrug resistance associated protein,
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